A hypersecretion of cortisol results in Cushingâ€™s syndrome. Hypersecretion can be caused due to various factors:
Corticosteroid medication: Cushing syndrome can be caused due to an external factor like high intake of corticosteroid medication over a prolonged period. These medicines can be important for many inflammatory diseases like asthma, rheumatoid arthritis and lupus. The cortisol content of these medicines is higher than what the body normally needs. Therefore, Cushingâ€™s syndrome can be formed.
Bodyâ€™s own production: in some cases, one or both of the adrenal glands produce high levels of cortisol, or overproduction of adrenocorticotropic hormone (ACTH). This can be due to many reasons:
A tumor on the pituitary gland. This can cause excess production of adrenocorticotropic hormone (ACTH) which in turn leads to hypersecretion of cortisol. This condition is mainly found in woman.
ACTH secreting tumor. A tumor growing in an organ not originally secreting ACTH will start secreting it in excess amounts.
Tumor on the adrenal gland. In some cases, the excess secretion of cortisol is not dependent on ACTH, but rather on the improper functioning of the adrenal glands.
The symptoms of Cushingâ€™s syndrome vary depending upon the level of cortisol released. The most common symptoms are:
- Weight gain with fat deposits specially in the mid-section of the back and face (rounded face)
- Purple or pink stretch marks all over the body, particularly on the stomach, breasts and thighs.
- Thinning of the skin and bruises are easily formed
- Slow healing of cuts
- Acne on the face
- Severe fatigue and muscle weakness
- Mental illnesses like depression and anxiety
- High blood pressure
The symptoms of Cushingâ€™s syndrome which are found in women:
- Menstrual cycle gets irregular or stops completely
- Production of thicker and visible facial and body hair.
The symptoms of Cushingâ€™s syndrome which are found in men:
- Erectile dysfunction
- Loss of libido
- Decrease in fertility
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