Acute deficiency of isoleucine, leucine, and valine, which are essential amino acids, often results in retarded growth, hair loss and anorexia. People with classic MSUD are prone to nutritional deficiencies. They often lack zinc, essential omega-3 fatty acids, as well as selenium and folic acid. From the observations made, it was found out that individuals with classic MSUD had a lower borne density than their peers who did not have the condition. This often resulted in frequent bone fractures, which caused transient leucosis. This condition is referred to as osteoporosis.
Oesophageal candidiasis is also a characteristic of individuals with MSUD. The candida can be attributed to the T-cell inhibitory effect due to high levels of leucine. It might also be due to iatrogenic immunodeficiency that results from the inadequate intake of branched-chain amino acids. Severe pancreatitis is also evident as they are treated for leucine intoxication. The condition emerges when the leucine levels are normalizing (King, 2012).
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