The mechanism underlying the abnormality in the sweat gland is the improper functioning of ion transport. Secretion occurs in the granular coil which â€œis modified as it traverses the sweat ductâ€ before being released on the surface of the skin (Quinton, 2007). In a person without CF, the sodium and chloride ions in that order are reabsorbed from the ductular lumen via CFTR and apical sodium channels. However, in a patient with CF the improper functioning of CFTR inhibits the reabsorption of the ions thus, the amount of salts that get absorbed is poor (Quinton, 2007). Consequently, a patientâ€™s sweat contains a high concentration of salt (Rowe, Miller & Sorscher, 2005).
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