These concepts usually fail due to insufï¬cient tissue renewal as a result of various complications, such as unwanted local tissue reactions, for instance acute inï¬‚ammatory reactions owing to macrophage extravasation, neutrophils, and adhesion, external cell growth, and ï¬brous capsule development (Mathur et al. 1997; Murugan & Ramakrishna 2005).
To summarise the hierarchical arrangement of original ECM, one method is to integrate nano-scale characteristics in the spatial support design. Generally, nano-tissues are defined as materials with plainly described characteristics between 1 and 100nm, including nano-spheres, nano-crystals, and nano-ï¬bres. Since normal collagen fibres fall within the range of 50â€“500nm, this review considers fibres in this submicron range and nano-tissues.
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